PT-141 PassionShot™: Complete Patient Guide

• (Bremelanotide Injectable Peptide Therapy)

• Important Safety Note

  This guide is for educational purposes and does not replace medical advice. Always follow your licensed provider’s instructions and reach out with questions.

• What is PT-141 PassionShot™?

  PT-141 (bremelanotide) is a prescription injectable peptide used to increase sexual desire and arousal. Unlike medications that affect hormones or blood flow, PT-141 works directly in the brain to activate desire through the nervous system — not the reproductive system.

  It’s a non-hormonal option designed especially for women who feel disconnected from their libido due to stress, hormonal shifts, or emotional fatigue. Some men use it too, but it is most commonly prescribed for female sexual interest and arousal concerns.

  📚 Clinical research:

  FDA Approval of Bremelanotide (Vyleesi) for HSDD:

  Clayton AH et al. (2016). "Efficacy and safety of bremelanotide for hypoactive sexual desire disorder: Two randomized phase 3 trials." J Sex Med.

• Who is it for?

  PT-141 PassionShot™ may be right for you if:

  • You’ve lost interest in intimacy and want to reconnect with that part of yourself

  • You’re not experiencing sexual desire like you used to, and it's affecting your relationship or self-esteem

  • You want a non-hormonal, on-demand option to feel more responsive and confident

  Many women use PT-141 during life transitions like postpartum recovery, perimenopause, menopause, or times of high stress. It’s about restoring your connection to your own desire — emotionally and physically.

• How Does It Work?

  PT-141 targets melanocortin receptors in the brain that are involved in sexual desire. This activation leads to an increase in libido and arousal — not by changing hormones, but by enhancing the brain’s responsiveness to sexual stimuli and emotional intimacy.

  It helps support the mental and emotional readiness for sex, making it especially effective for women who feel “mentally checked out” of intimacy despite wanting to feel differently.

  📚 Mechanism of Action Reference:

  Kingsberg SA et al. (2019). "Mechanism of action and clinical efficacy of bremelanotide for hypoactive sexual desire disorder." Expert Opin Drug Metab Toxicol.

• How to Use PT-141

  PT-141 is a subcutaneous injection (under the skin) and is used as needed — not daily.

  General Use Instructions:

  • Inject 45–60 minutes before planned intimacy

  • Use no more than 8 doses per month (or as advised by your provider)

  • Most patients use it 1–2 times per week

  • Inject into the stomach area or thigh using a small insulin syringe

  Your provider will give you instructions tailored to your lifestyle and needs.

• What’s Included in Your Kit?

  • Multi-dose vial(s) of PT-141 (compounded in the USA)
  • Insulin syringes and alcohol swabs
  • Instructions for safe self-injection
  • Provider consultation and approval
  • Discreet, tracked shipping
  • Ongoing support from our team

• What Results Can I Expect?

  • Within the first use: You may notice a shift in mental readiness, interest in intimacy, or improved arousal response

  • Over 2–4 weeks: Many patients report feeling more “tuned in” to their body, more emotionally open, and more easily engaged in intimacy

  • Long-term: PT-141 can help re-establish a pattern of enjoyable sexual experiences, rebuilding confidence and connection

  PT-141 isn’t about forcing instant arousal — it’s about gently reconnecting your mind and body so that desire can come more naturally, when the moment is right.

• Potential Side Effects

  Most users tolerate PT-141 well. Possible side effects include:

  • Nausea (most common — often avoided by injecting after a light snack)
  • Headache
  • Flushing or warmth in the face
  • Temporary rise in blood pressure

  These effects typically pass quickly. If symptoms persist or worsen, contact your provider.

• When NOT to Use PT-141:

  • If you’re pregnant or breastfeeding
  • If you have uncontrolled high blood pressure
  • If you’ve had a recent stroke or heart attack
  • If you're allergic to bremelanotide or any ingredients in the formulation

  Always consult your provider before starting if you have a chronic condition or take other medications.

• Can PT-141 Be Combined with Other Medications?

  Yes — PT-141 (Bremelanotide) is commonly used alongside other peptides and wellness therapies. It works through unique neural pathways to stimulate sexual arousal and is not known to interfere with most other injectables. Below is a breakdown of its compatibility with other FancyMeds offerings.

  
  

  ✅ Safe and Effective Combinations:

  • NAD+ (CellFuel™) - NAD+ improves cellular energy, brain function, and stress resilience — which may enhance PT-141’s effects on libido and mood. These two can be safely used together, particularly for those with fatigue or brain fog contributing to low sexual desire.

  📚 References:

  Braidy N et al., 2019 – NAD+ in cognitive and mood health (NCBI)

  Revive Therapeutics, 2020 – PT-141 and mood/arousal effects (ClinicalTrials.gov)

  • Sermorelin (AgeDefy™) - Sermorelin supports hormone balance, sleep, and tissue repair, while PT-141 targets the brain’s arousal centers. Together, they may help restore energy, sexual desire, and sleep quality, especially in perimenopausal or andropausal individuals.

  📚 References:

  Walker RF et al., 2001 – Sermorelin and age-related hormone decline (PubMed)

  Shadiack AM et al., 2007 – PT-141 and sexual response (PubMed)

  • GHK-Cu (SkinRevive™) - There are no known interactions between GHK-Cu and PT-141. Some users report improved confidence and appearance from GHK-Cu, which may complement the psychological aspects of arousal and self-esteem impacted by PT-141.

  📚 References:

  Pickart L, 2008 – GHK-Cu in skin remodeling (PubMed)

  ⚠️ Use with Monitoring or Provider Input:

  • Semaglutide / Tirzepatide (GLP-1 Medications) - GLP-1 medications may cause fatigue, low libido, or emotional blunting in some users — the very issues PT-141 is designed to help with. While there’s no pharmacological interaction, patient experience should be monitored, especially for:
  • Nausea or reduced appetite (which can interfere with mood)
  • Hormonal effects or mood changes
  • Blood pressure, as both PT-141 and GLP-1s may mildly affect cardiovascular function

  📚 References:

  Nauck MA et al., 2021 – GLP-1 agonist effects (NEJM)

  FDA PT-141 Label – Cardiovascular considerations

  • Glutathione - Glutathione is safe to use alongside PT-141. It may reduce oxidative stress, detoxify the body, and support immune and liver health — potentially counteracting side effects like headache, inflammation, or fatigue. No known contraindications exist.

  📚 References:

  Wu G et al., 2004 – Glutathione metabolism and antioxidant functions (NCBI)

  Richie JP et al., 2015 – Glutathione supplementation study (PubMed)

• Final Word

  PT-141 can be a powerful addition to your wellness protocol. If you’re using it alongside energy, hormone, or skin treatments, it’s generally safe — but combining therapies should be guided by your health history and treatment goals.

  Need help building the right stack? Our provider team can tailor a personalized plan for you. 💬